Starting in the middle of the last century, humanity embarked upon the largely serendipitous development of a wide spectrum of massively disruptive technologies, including information technology, biotechnology, nanotechnology, quantum computing, and energy technologies. These are projected to alter nearly everything, including precepts of the human existence theorem.
Dennis Bushnell's blog
With the possible exception of interestellar propulsion, science fact is now outpacing science fiction. Now, when we scientists meet with science-fiction folks to discuss possible scenarios, we end up giving them ideas more often than not.